Q-omics provides the consensus-scored HOMER2P1 profile across patient tissues and cancer cell-line models. HOMER2P1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, HOMER2P1 is differentially expressed in 6, with the highest sampling consensus in THCA. Additionally, HOMER2P1 RNA expression shows 10,179 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KICH, THCA, and TGCT as cancer lineages where HOMER2P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOMER2P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOMER2P1 survival associations across molecular data types. HOMER2P1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOMER2P1 RNA expression–survival associations across cancer types. High HOMER2P1 expression shows unfavorable associations in KICH, DLBC, SKCM and PAAD, but favorable associations in LUAD and BRCA. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .004). Together, the overview and detailed table identify KICH as the clearest survival context for HOMER2P1 RNA expression.
This table summarizes HOMER2P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for HOMER2P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOMER2P1 shows lower tumor expression in THCA and higher tumor expression in BRCA, LIHC, LUAD, LUSC and HNSC. The THCA box plot shows higher HOMER2P1 RNA expression in normal versus tumor tissue (log2 FC = −0.026, t-test p = .006).
This table shows molecular features associated with HOMER2P1 in patient tissues and cancer cell lines. In patient samples, HOMER2P1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
