HOMER2

Across TCGA pan-cancer cohorts, HOMER2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HOMER2 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HOMER2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HOMER2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where HOMER2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.444	.018	18	view →
LUAD	OS	Tertile	All	0.902	0.553	<.001	16	view →
PDAC	OS	Tertile	IV	0.491	0.836	.024	6	view →
LSCC	OS	Tertile	All	1.000	0.914	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HOMER2–UCEC (DFS)

Open the UCEC breakdown →