HOMER2

Across TCGA patient cohorts, HOMER2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOMER2-associated genes across cancer lineages are JNK_pT183_Y185, Rictor_pT1135, and ATM. Each is linked with HOMER2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOMER2-to-partner and partner-to-HOMER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by HOMER2-low versus HOMER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER2→partner) and Y-score (partner→HOMER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.194	-3.169	.017	.019	3	3
UCEC	Rictor_pT1135 →	-0.116	-3.169	.018	.019	3	2
UCEC	ATM →	-0.653	-2.986	.002	.035	3	2
SKCM	Caspase-7-cleavedD198 →	+0.614	+2.832	.041	.034	3	2
UCEC	eIF4E →	+0.209	+3.000	.040	.036	2	2
UCEC	GSK-3a-b_pS21_S9 →	+0.564	+2.331	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK_pT183_Y185 by HOMER2 expression — UCEC

Explore this box plot interactively →