HOMER2

Across TCGA cell cohorts, HOMER2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,466 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOMER2-associated GO terms across cancer lineages are Regulation of store-operated calcium entry, Cytoplasmic translation, and Epigenetic regulation of gene expression. Each is linked with HOMER2 in more than 10 cancer types. Because this analysis shows association rather than direction, both HOMER2-to-partner and partner-to-HOMER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of store-operated calcium entry grouped by HOMER2-low versus HOMER2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER2→partner) and Y-score (partner→HOMER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of store-operated calcium entry →	+0.153	+2.064	.003	.005	3	11
STOMACH	Cytoplasmic translation →	+0.104	+2.813	.001	<.001	3	11
BLOOD_Lymphoma	Epigenetic regulation of gene expression →	+0.057	+2.023	<.001	<.001	3	11
OESOPHAGUS	Establishment of protein localization to organelle →	+0.064	+2.062	.004	.004	3	10
PANCREAS	Nucleoside triphosphate metabolic process →	+0.089	+1.681	<.001	<.001	3	10
OESOPHAGUS	Positive regulation of T-helper 17 cell lineage commitment →	+0.263	+2.118	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

Regulation of store-operated calcium entry by HOMER2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →