HOGA1

Across TCGA patient cohorts, HOGA1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOGA1-associated genes across cancer lineages are MSH6, Notch1, and ATM. Each is linked with HOGA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOGA1-to-partner and partner-to-HOGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by HOGA1-low versus HOGA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOGA1→partner) and Y-score (partner→HOGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.455	-2.115	<.001	.016	3	2
UCEC	Notch1 →	+0.133	+1.415	.011	.046	3	2
UCEC	ATM →	-0.529	-2.169	.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.465	+1.604	.036	.041	3	2
UCEC	Caspase-8 →	-0.231	-2.807	.014	.003	3	2
UCEC	c-Met_pY1235 →	+0.079	+1.817	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH6 by HOGA1 expression — UCEC

Explore this box plot interactively →