HNRNPU

Across TCGA pan-cancer cohorts, HNRNPU mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPU data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPU mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HNRNPU expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where HNRNPU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.609	0.864	.002	33	view →
LUAD	OS	Tertile	All	1.000	0.698	.004	17	view →
PDAC	DFS	Quartile	All	0.910	0.735	.003	8	view →
UCEC	DFS	Quartile	II,III,IV	0.499	1.000	.025	4	view →
LSCC	OS	Quartile	II,III,IV	0.917	0.610	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPU–HNSC (OS)

Open the HNSC breakdown →