HNRNPU

Across TCGA patient cohorts, HNRNPU mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPU-associated genes across cancer lineages are ATM, eIF4E, and JNK2. Each is linked with HNRNPU in more than 2 cancer types. Because this analysis shows association rather than direction, both HNRNPU-to-partner and partner-to-HNRNPU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HNRNPU-low versus HNRNPU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPU→partner) and Y-score (partner→HNRNPU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.560	-2.000	<.001	<.001	3	3
UCEC	eIF4E →	+0.187	+2.247	.006	.001	3	2
UCEC	JNK2 →	+0.199	+1.459	.001	.012	3	2
UCEC	A-Raf_pS299 →	-0.094	-1.584	.015	.034	3	1
UCEC	Fibronectin →	-0.303	-2.238	.004	.001	3	1
UCEC	IGFBP2 →	-0.594	-1.222	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by HNRNPU expression — UCEC

Explore this box plot interactively →