HNRNPM

Across TCGA pan-cancer cohorts, HNRNPM mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HNRNPM data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPM expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where HNRNPM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.663	0.902	<.001	75	view →
LSCC	OS	Quartile	II,III,IV	0.908	0.449	.022	14	view →
PDAC	OS	Median	IV	0.951	0.381	.006	12	view →
CCRCC	OS	Median	All	0.909	1.000	.019	7	view →
GBM	OS	Quartile	All	0.643	0.323	.008	5	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.887	.043	3	view →
UCEC	DFS	Median	All	1.000	0.939	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HNRNPM–HNSC (DFS)

Open the HNSC breakdown →