HNRNPM

Across TCGA patient cohorts, HNRNPM mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPM-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and JNK2. Each is linked with HNRNPM in more than 3 cancer types. Because this analysis shows association rather than direction, both HNRNPM-to-partner and partner-to-HNRNPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HNRNPM-low versus HNRNPM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPM→partner) and Y-score (partner→HNRNPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.398	+1.341	.028	.043	3	4
UCEC	4E-BP1 →	+0.205	+2.584	.013	.010	3	3
UCEC	JNK2 →	+0.141	+1.064	.020	.048	3	2
UCEC	p90 RSK →	+0.127	+1.487	.030	.004	3	2
UCEC	Rad50 →	-0.175	-1.263	.018	.019	3	2
UCEC	ATM →	-0.437	-2.571	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by HNRNPM expression — UCEC

Explore this box plot interactively →