HNRNPM

Across TCGA cell cohorts, HNRNPM mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HNRNPM-associated genes across cancer lineages are IQCF5, OTOR, and OR4X2. Each is linked with HNRNPM in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPM-to-partner and partner-to-HNRNPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by HNRNPM-low versus HNRNPM-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPM→partner) and Y-score (partner→HNRNPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	2
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	MAGEB18 →	+0.042	+4.222	.001	.007	3	1
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	OR10J3 →	+0.016	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

IQCF5 by HNRNPM expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →