HNRNPLP1

Across TCGA pan-cancer cohorts, HNRNPLP1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HNRNPLP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HNRNPLP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPLP1 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

HNSC, LUSC, and COAD are the cancer types where HNRNPLP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPLP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.156	<.001	8	view →
LUSC	All	All	+0.184	<.001	7	view →
COAD	Female	II,III,IV	+0.454	<.001	5	view →
READ	All	II,III,IV	+0.230	.001	4	view →
LUAD	All	All	+0.075	.001	4	view →
BRCA	All	All	+0.034	.003	4	view →
PAAD	Female	All	−0.145	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HNRNPLP1–HNSC

Open the HNSC breakdown →