HNRNPL

Across TCGA pan-cancer cohorts, HNRNPL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HNRNPL data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HNRNPL expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

HNSC, COAD, and LUAD are the cancer types where HNRNPL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.601	0.873	<.001	57	view →
COAD	DFS	Tertile	All	1.000	0.864	.042	12	view →
LUAD	DFS	Tertile	III,IV	0.265	0.899	.038	9	view →
GBM	OS	Tertile	All	0.524	0.285	.011	9	view →
PDAC	DFS	Quartile	All	0.938	0.753	.028	5	view →
LSCC	DFS	Tertile	II,III,IV	0.851	0.546	.025	3	view →
CCRCC	OS	Quartile	III,IV	1.000	0.662	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HNRNPL–HNSC (OS)

Open the HNSC breakdown →