HNRNPL

Across TCGA patient cohorts, HNRNPL mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPL-associated genes across cancer lineages are MEK1, PCNA, and Annexin-1. Each is linked with HNRNPL in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPL-to-partner and partner-to-HNRNPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HNRNPL-low versus HNRNPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPL→partner) and Y-score (partner→HNRNPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.348	+1.874	.004	.002	3	2
UCEC	PCNA →	+0.175	+1.906	.015	.015	3	2
UCEC	Annexin-1 →	+0.483	+1.604	.006	.041	3	2
UCEC	S6_pS240_S244 →	+0.420	+2.201	.001	<.001	3	2
UCEC	EGFR →	-0.197	-2.201	<.001	<.001	3	1
UCEC	ERK2 →	+0.161	+2.000	.012	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by HNRNPL expression — UCEC

Explore this box plot interactively →