HNRNPL

Across TCGA cell cohorts, HNRNPL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,634 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HNRNPL-associated GO terms across cancer lineages are DNA-templated DNA replication, Mitotic DNA integrity checkpoint signaling, and Cell cycle DNA replication. Each is linked with HNRNPL in more than 19 cancer types. Because this analysis shows association rather than direction, both HNRNPL-to-partner and partner-to-HNRNPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by HNRNPL-low versus HNRNPL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPL→partner) and Y-score (partner→HNRNPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.113	+0.856	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA integrity checkpoint signaling →	+0.093	+0.930	<.001	<.001	3	19
BONE	Cell cycle DNA replication →	+0.136	+0.421	<.001	.004	3	19
URINARY_TRACT	DNA replication →	+0.099	+0.773	<.001	.003	3	19
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.174	+0.677	<.001	<.001	3	19
BONE	Regulation of DNA replication →	+0.107	+0.784	.004	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,634 associations by consensus.

DNA-templated DNA replication by HNRNPL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →