HNRNPL

Across TCGA cell cohorts, HNRNPL mutation is significantly associated with the mutation status of many other genes, with 2,610 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HNRNPL-associated genes across cancer lineages are UBA6, FGFR1, and STRIP2. Each is linked with HNRNPL in more than 3 cancer types. Because this analysis shows association rather than direction, both HNRNPL-to-partner and partner-to-HNRNPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBA6 grouped by HNRNPL-low versus HNRNPL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPL→partner) and Y-score (partner→HNRNPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBA6 →	+4.560	+4.309	.007	.007	1	4
UPPER_AERODIGESTIVE_TRACT	FGFR1 →	+4.954	+4.392	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	STRIP2 →	+4.954	+4.392	.008	.008	1	4
OVARY	DCLRE1B →	+5.415	+5.415	.004	.004	1	4
LARGE_INTESTINE	CPS1 →	+2.043	+3.693	.009	.009	1	4
BLOOD_Leukemia	C3 →	+3.390	+5.080	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,610 associations by consensus.

UBA6 by HNRNPL expression — BLOOD_Leukemia

Explore this box plot interactively →