HNRNPKP3

Across TCGA patient cohorts, HNRNPKP3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPKP3-associated genes across cancer lineages are EGFR_pY1068, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with HNRNPKP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPKP3-to-partner and partner-to-HNRNPKP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HNRNPKP3-low versus HNRNPKP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPKP3→partner) and Y-score (partner→HNRNPKP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-3.321	.037	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.763	-3.000	.001	.036	3	1
UCEC	PDCD4 →	-0.757	-2.990	.002	.036	3	1
UCEC	CD49b →	-0.317	-3.308	.033	.010	3	1
UCEC	Caspase-8 →	-0.295	-3.321	.025	.010	2	1
UCEC	Ku80 →	+0.299	+3.335	.015	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by HNRNPKP3 expression — UCEC

Explore this box plot interactively →