HNRNPK

Across TCGA pan-cancer cohorts, HNRNPK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPK data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HNRNPK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HNRNPK expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where HNRNPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.923	.002	25	view →
COAD	DFS	Median	All	1.000	0.887	.021	24	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	8	view →
GBM	OS	Quartile	All	0.560	0.322	.036	3	view →
PDAC	OS	Tertile	IV	0.962	0.425	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPK–LUAD (OS)

Open the LUAD breakdown →