HNRNPK

Across TCGA patient cohorts, HNRNPK mutation is significantly associated with the RNA expression of many other genes, with 1,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPK-associated genes across cancer lineages are PPP2R5E, CENPN, and GLOD4. Each is linked with HNRNPK in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPK-to-partner and partner-to-HNRNPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5E grouped by HNRNPK-low versus HNRNPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPK→partner) and Y-score (partner→HNRNPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R5E →	+0.437	+2.823	.004	.001	3	2
UCEC	CENPN →	+0.733	+2.343	<.001	.003	3	2
UCEC	GLOD4 →	+0.401	+3.008	.005	<.001	3	2
UCEC	FAXDC2 →	-0.655	-2.169	<.001	.003	3	2
UCEC	PGAM1 →	+0.677	+2.243	.003	.005	3	2
UCEC	ZBTB8OS →	+0.440	+3.938	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,685 associations by consensus.

PPP2R5E by HNRNPK expression — UCEC

Explore this box plot interactively →