HNRNPH3

Across TCGA patient cohorts, HNRNPH3 mutation is significantly associated with the RNA expression of many other genes, with 2,402 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPH3-associated genes across cancer lineages are NF2, PLA2G12AP1, and CYP27B1. Each is linked with HNRNPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPH3-to-partner and partner-to-HNRNPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by HNRNPH3-low versus HNRNPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPH3→partner) and Y-score (partner→HNRNPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.691	+3.180	<.001	<.001	3	2
UCEC	PLA2G12AP1 →	+0.338	+2.064	.005	.005	3	2
UCEC	CYP27B1 →	+0.566	+2.534	<.001	.001	3	2
LUSC	RNU6-365P →	+0.397	+7.924	<.001	.008	3	2
UCEC	GFI1 →	+0.772	+3.191	<.001	<.001	3	2
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,402 associations by consensus.

NF2 by HNRNPH3 expression — UCEC

Explore this box plot interactively →