HNRNPH3

Across TCGA patient cohorts, HNRNPH3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPH3-associated genes across cancer lineages are ATM, eEF2, and Heregulin. Each is linked with HNRNPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPH3-to-partner and partner-to-HNRNPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HNRNPH3-low versus HNRNPH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPH3→partner) and Y-score (partner→HNRNPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.621	-2.584	.003	.011	3	2
UCEC	eEF2 →	+0.369	+3.169	.026	.019	3	1
UCEC	Heregulin →	-0.124	-2.986	.031	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.233	-3.169	.003	.018	3	1
UCEC	Ku80 →	+0.316	+3.331	.004	.005	3	1
UCEC	Notch1 →	+0.182	+3.013	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by HNRNPH3 expression — UCEC

Explore this box plot interactively →