HNRNPH3

Across TCGA cell cohorts, HNRNPH3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HNRNPH3-associated genes across cancer lineages are DEFA4, BPIFA1, and SCGB3A2. Each is linked with HNRNPH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPH3-to-partner and partner-to-HNRNPH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by HNRNPH3-low versus HNRNPH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPH3→partner) and Y-score (partner→HNRNPH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPIFA1 →	+0.191	+4.273	<.001	.006	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.100	+4.922	.003	.009	3	1
BLOOD_Leukemia	KRTAP4-9 →	+0.048	+5.201	<.001	.006	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DEFA4 by HNRNPH3 expression — LARGE_INTESTINE

Explore this box plot interactively →