HNRNPH2

Across TCGA cell cohorts, HNRNPH2 mutation is significantly associated with the mutation status of many other genes, with 2,438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNRNPH2-associated genes across cancer lineages are ADAMTS12, SNED1, and DENND4A. Each is linked with HNRNPH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HNRNPH2-to-partner and partner-to-HNRNPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTS12 grouped by HNRNPH2-low versus HNRNPH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPH2→partner) and Y-score (partner→HNRNPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAMTS12 →	+1.781	+3.602	.006	.006	1	3
LARGE_INTESTINE	SNED1 →	+2.781	+4.504	<.001	<.001	1	3
LARGE_INTESTINE	DENND4A →	+1.781	+3.602	.006	.006	1	3
LARGE_INTESTINE	GRIN2A →	+2.080	+3.906	.003	.003	1	3
LARGE_INTESTINE	ACACA →	+2.080	+3.906	.003	.003	1	3
UPPER_AERODIGESTIVE_TRACT	FOXF1 →	+5.392	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

ADAMTS12 by HNRNPH2 expression — LARGE_INTESTINE

Explore this box plot interactively →