HNRNPH1

Across TCGA patient cohorts, HNRNPH1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPH1-associated genes across cancer lineages are ATM, FOXO3a_pS318_S321, and ACC1. Each is linked with HNRNPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPH1-to-partner and partner-to-HNRNPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HNRNPH1-low versus HNRNPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPH1→partner) and Y-score (partner→HNRNPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.409	-1.906	.025	.016	3	2
UCEC	FOXO3a_pS318_S321 →	-0.110	-1.990	.028	.030	3	1
UCEC	ACC1 →	+0.414	+2.335	.004	.018	3	1
UCEC	JNK2 →	+0.226	+2.415	.004	.003	3	1
UCEC	p62 Lck ligand →	+0.583	+3.584	<.001	.002	3	1
UCEC	PCNA →	+0.177	+1.906	.042	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by HNRNPH1 expression — UCEC

Explore this box plot interactively →