HNRNPF

Across TCGA pan-cancer cohorts, HNRNPF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPF data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPF expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where HNRNPF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.481	0.729	.004	26	view →
LUAD	DFS	Median	III,IV	0.973	0.508	.032	5	view →
LSCC	DFS	Median	All	0.902	0.469	.010	4	view →
GBM	DFS	Quartile	All	0.503	0.220	.029	3	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPF–HNSC (DFS)

Open the HNSC breakdown →