HNRNPF

Across TCGA patient cohorts, HNRNPF mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPF-associated genes across cancer lineages are ATM, Lck, and MEK1. Each is linked with HNRNPF in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPF-to-partner and partner-to-HNRNPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HNRNPF-low versus HNRNPF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPF→partner) and Y-score (partner→HNRNPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.426	-1.847	.010	.008	3	2
UCEC	Lck →	+0.202	+2.459	.006	.018	3	1
UCEC	MEK1 →	+0.555	+3.392	<.001	<.001	3	1
UCEC	MSH2 →	-0.324	-3.880	<.001	<.001	3	1
UCEC	MSH6 →	-0.348	-2.574	.004	.010	3	1
UCEC	mTOR_pS2448 →	-0.108	-2.202	.048	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by HNRNPF expression — UCEC

Explore this box plot interactively →