Across TCGA pan-cancer cohorts, HNRNPDLP2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HNRNPDLP2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where HNRNPDLP2 RNA is repressed in tumor relative to normal tissue. In most cancer types HNRNPDLP2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.
KICH and BRCA are the cancer types where HNRNPDLP2 tumor–normal differential expression is most reproducible.