HNRNPDL

Across TCGA pan-cancer cohorts, HNRNPDL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HNRNPDL data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HNRNPDL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HNRNPDL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where HNRNPDL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.752	0.354	.006	28	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	19	view →
GBM	OS	Tertile	All	0.560	0.280	.009	12	view →
PDAC	DFS	Median	III,IV	0.227	0.476	.007	11	view →
OV	DFS	Median	All	0.486	0.900	.015	8	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HNRNPDL–CCRCC (DFS)

Open the CCRCC breakdown →