HNRNPCL4

Across TCGA pan-cancer cohorts, HNRNPCL4 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HNRNPCL4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPCL4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPCL4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

HNSC, KICH, and UVM are the cancer types where HNRNPCL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.362	0.672	.001	99	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
UVM	OS	Tertile	All	0.305	0.796	.001	90	view →
COAD	DFS	Tertile	IV	0.190	0.511	.002	81	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	72	view →
LIHC	OS	Tertile	III,IV	0.309	0.642	.007	51	view →
LUAD	OS	Tertile	III,IV	1.000	0.449	.019	33	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
LUSC	DFS	Tertile	All	0.816	0.647	.029	12	view →
STAD	DFS	Tertile	All	0.716	0.387	.029	12	view →
ACC	DFS	Tertile	III,IV	0.057	0.457	.040	9	view →
SARC	OS	Tertile	All	0.207	0.610	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HNRNPCL4–HNSC (DFS)

Open the HNSC breakdown →