HNRNPCL2

Across TCGA patient cohorts, HNRNPCL2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HNRNPCL2-associated genes across cancer lineages are cIAP, GSK-3_pS9, and MYH11. Each is linked with HNRNPCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPCL2-to-partner and partner-to-HNRNPCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by HNRNPCL2-low versus HNRNPCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPCL2→partner) and Y-score (partner→HNRNPCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.176	+2.833	.037	.035	3	1
SKCM	GSK-3_pS9 →	-0.561	-2.425	.009	.020	3	1
SKCM	MYH11 →	-0.829	-2.459	.045	.020	3	1
SKCM	AMPK_alpha →	+0.230	+3.000	<.001	.035	3	1
SKCM	c-Myc →	+0.266	+2.459	.046	.020	3	1
SKCM	DJ-1 →	+0.288	+3.000	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

cIAP by HNRNPCL2 expression — UCEC

Explore this box plot interactively →