HNRNPC

Across TCGA pan-cancer cohorts, HNRNPC mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HNRNPC data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPC expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where HNRNPC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.361	0.895	.007	14	view →
UCEC	DFS	Quartile	III,IV	0.358	1.000	.040	4	view →
PDAC	OS	Median	III,IV	0.788	0.381	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HNRNPC–HNSC (DFS)

Open the HNSC breakdown →