HNRNPC

Across TCGA pan-cancer cohorts, HNRNPC mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HNRNPC’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HNRNPC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPC is over-expressed in tumor.

COAD, HNSC, and LUAD are the cancer types where HNRNPC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.614	<.001	11	view →
HNSC	Male	III,IV	+0.326	<.001	11	view →
LUAD	Male	III,IV	+0.586	<.001	9	view →
LSCC	Male	II,III,IV	+0.559	<.001	9	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HNRNPC–COAD

Open the COAD breakdown →