HNRNPC

Across TCGA patient cohorts, HNRNPC mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPC-associated genes across cancer lineages are 14-3-3_beta, EGFR, and GAPDH. Each is linked with HNRNPC in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPC-to-partner and partner-to-HNRNPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by HNRNPC-low versus HNRNPC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPC→partner) and Y-score (partner→HNRNPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.119	-3.295	.005	.009	3	1
UCEC	EGFR →	-0.195	-2.321	.004	.034	3	1
UCEC	GAPDH →	+0.451	+2.321	.048	.034	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.400	+2.906	.027	.001	3	1
UCEC	Heregulin →	-0.156	-2.000	.002	.030	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.663	+2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by HNRNPC expression — UCEC

Explore this box plot interactively →