HNRNPC

Across TCGA cell cohorts, HNRNPC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,315 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HNRNPC-associated GO terms across cancer lineages are DNA-templated DNA replication, Protein localization to condensed chromosome, and Protein localization to kinetochore. Each is linked with HNRNPC in more than 16 cancer types. Because this analysis shows association rather than direction, both HNRNPC-to-partner and partner-to-HNRNPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by HNRNPC-low versus HNRNPC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPC→partner) and Y-score (partner→HNRNPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.099	+0.806	<.001	<.001	3	17
SKIN	Protein localization to condensed chromosome →	+0.161	+0.775	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Protein localization to kinetochore →	+0.168	+0.660	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.146	+0.920	<.001	<.001	3	17
KIDNEY	Attachment of spindle microtubules to kinetochore →	+0.140	+0.771	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.190	+1.146	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,315 associations by consensus.

DNA-templated DNA replication by HNRNPC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →