HNRNPA3

Across TCGA pan-cancer cohorts, HNRNPA3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPA3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HNRNPA3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HNRNPA3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where HNRNPA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.930	0.689	.002	27	view →
LUAD	DFS	Median	All	0.862	0.519	.002	21	view →
HNSC	OS	Tertile	III,IV	0.755	0.928	.033	16	view →
GBM	OS	Median	All	0.484	0.289	.008	11	view →
PDAC	OS	Tertile	All	0.452	0.278	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPA3–LSCC (DFS)

Open the LSCC breakdown →