HNRNPA3

Across TCGA patient cohorts, HNRNPA3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNRNPA3-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and eIF4E. Each is linked with HNRNPA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HNRNPA3-to-partner and partner-to-HNRNPA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HNRNPA3-low versus HNRNPA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNRNPA3→partner) and Y-score (partner→HNRNPA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.461	+3.169	.025	.018	3	2
UCEC	EGFR_pY1068 →	-0.228	-1.502	.013	.030	3	1
UCEC	eIF4E →	+0.197	+1.847	.010	.008	3	1
UCEC	JNK2 →	+0.184	+1.847	.011	.008	3	1
UCEC	MEK1 →	+0.330	+2.115	.014	.017	3	1
UCEC	p62 Lck ligand →	+0.462	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Cyclin-B1 by HNRNPA3 expression — UCEC

Explore this box plot interactively →