Across TCGA pan-cancer cohorts, HNRNPA1P70 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HNRNPA1P70’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where HNRNPA1P70 RNA is repressed in tumor relative to normal tissue. In most cancer types HNRNPA1P70 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.
COAD, KIRC, and LUAD are the cancer types where HNRNPA1P70 tumor–normal differential expression is most reproducible.