Across TCGA pan-cancer cohorts, HNRNPA1P60 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HNRNPA1P60’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where HNRNPA1P60 RNA is repressed in tumor relative to normal tissue. In most cancer types HNRNPA1P60 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
PAAD, BLCA, and LUSC are the cancer types where HNRNPA1P60 tumor–normal differential expression is most reproducible.