HNRNPA1P53

Across TCGA pan-cancer cohorts, HNRNPA1P53 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HNRNPA1P53’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where HNRNPA1P53 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HNRNPA1P53 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

CHOL, BRCA, and LUAD are the cancer types where HNRNPA1P53 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HNRNPA1P53 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	+0.206	<.001	5	view →
BRCA	All	II,III,IV	+0.072	.010	4	view →
LUAD	All	All	+0.141	.009	2	view →
KICH	All	All	−0.081	.030	2	view →
LIHC	All	All	+0.050	.005	2	view →
COAD	Male	III,IV	+0.147	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HNRNPA1P53–CHOL

Open the CHOL breakdown →