Across TCGA pan-cancer cohorts, HNRNPA1P31 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HNRNPA1P31’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where HNRNPA1P31 RNA is repressed in tumor relative to normal tissue. In most cancer types HNRNPA1P31 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where HNRNPA1P31 tumor–normal differential expression is most reproducible.