HNRNPA1L2

Across TCGA pan-cancer cohorts, HNRNPA1L2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HNRNPA1L2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HNRNPA1L2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HNRNPA1L2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where HNRNPA1L2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.363	1.000	.003	66	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.891	.025	6	view →
UCEC	DFS	Quartile	All	0.927	0.729	.045	4	view →
GBM	OS	Median	All	0.657	0.414	.007	4	view →
LUAD	OS	Quartile	All	0.628	0.927	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HNRNPA1L2–HNSC (DFS)

Open the HNSC breakdown →