HNF4A

Across TCGA patient cohorts, HNF4A RNA expression is significantly associated with the protein abundance of many other proteins, with 7,612 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HNF4A-associated proteins across cancer lineages are PLEKHA1, USH1C_S201, and KLC4. Each is linked with HNF4A in more than 3 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HNF4A versus PLEKHA1 in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEKHA1 →	+0.388	+0.058	.004	.004	3	4
LUAD	USH1C_S201 →	+2.654	+3.842	.008	<.001	3	4
PDAC	KLC4 →	+0.294	+0.794	<.001	<.001	3	4
PDAC	CES2 →	+1.166	+1.102	<.001	<.001	3	4
PDAC	KBTBD11 →	+0.396	+0.881	<.001	<.001	3	4
LUAD	VIL1 →	+1.454	+1.260	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,612 associations by consensus.

HNF4A vs PLEKHA1 — GBM

Explore this scatter interactively →