HNF4A

Across TCGA patient cohorts, HNF4A mutation is significantly associated with the RNA expression of many other genes, with 3,322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF4A-associated genes across cancer lineages are SMC5-AS1, BUB3, and CCNF. Each is linked with HNF4A in more than 2 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMC5-AS1 grouped by HNF4A-low versus HNF4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC5-AS1 →	+0.345	+2.010	<.001	<.001	3	3
UCEC	BUB3 →	+0.403	+2.245	<.001	.001	3	3
UCEC	CCNF →	+0.562	+3.191	<.001	<.001	3	3
UCEC	STOML2 →	+0.440	+1.999	<.001	<.001	3	3
UCEC	MELK →	+0.693	+3.332	<.001	<.001	3	3
UCEC	PLK1 →	+0.666	+3.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,322 associations by consensus.

SMC5-AS1 by HNF4A expression — UCEC

Explore this box plot interactively →