HNF4A

Across TCGA patient cohorts, HNF4A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HNF4A-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and TAZ. Each is linked with HNF4A in more than 3 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HNF4A-low versus HNF4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.908	+2.584	<.001	<.001	3	4
LUAD	4E-BP1 →	+0.351	+3.012	.017	.018	3	3
LUAD	TAZ →	+0.187	+2.832	.018	.034	3	2
LUAD	YAP_pS127 →	-0.367	-3.321	.041	.010	3	2
SKCM	Src →	-0.253	-3.442	.003	.004	3	2
UCEC	GSK3-a-b →	-0.115	-2.222	.011	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by HNF4A expression — UCEC

Explore this box plot interactively →