HNF4A

Across TCGA cell cohorts, HNF4A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,569 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNF4A-associated GO terms across cancer lineages are Positive regulation of amino acid metabolic process, Negative regulation of epithelial to mesenchymal transition, and Renal D-glucose absorption. Each is linked with HNF4A in more than 6 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of amino acid metabolic process grouped by HNF4A-low versus HNF4A-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of amino acid metabolic process →	-0.258	-3.356	<.001	<.001	3	7
LIVER	Negative regulation of epithelial to mesenchymal transition →	+0.171	+4.667	<.001	<.001	3	6
LIVER	Renal D-glucose absorption →	+1.741	+3.917	<.001	<.001	3	6
LIVER	Regulation of phospholipid metabolic process →	+0.158	+4.600	<.001	<.001	3	6
STOMACH	GDP-L-fucose metabolic process →	+0.085	+2.966	<.001	<.001	3	6
STOMACH	Telomere assembly →	-0.087	-3.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,569 associations by consensus.

Positive regulation of amino acid metabolic process by HNF4A expression — LIVER

Explore this box plot interactively →