HNF4A

Across TCGA cell cohorts, HNF4A mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HNF4A-associated genes across cancer lineages are PLA2G2C, MRGPRX2, and GLT6D1. Each is linked with HNF4A in more than 1 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G2C grouped by HNF4A-low versus HNF4A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PLA2G2C →	+0.003	+4.169	<.001	.008	3	2
SOFT_TISSUE	MRGPRX2 →	+0.066	+5.169	<.001	<.001	3	1
SOFT_TISSUE	GLT6D1 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR5H6 →	+0.016	+4.369	<.001	.008	3	1
CNS	APOBEC1 →	+0.013	+4.169	<.001	.008	3	1
CNS	OR52E4 →	+0.029	+4.566	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PLA2G2C by HNF4A expression — CNS

Explore this box plot interactively →