HNF4A

Across TCGA cell cohorts, HNF4A mutation is significantly associated with the mutation status of many other genes, with 2,864 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HNF4A-associated genes across cancer lineages are ZSWIM8, TRPV3, and SH3TC1. Each is linked with HNF4A in more than 3 cancer types. Because this analysis shows association rather than direction, both HNF4A-to-partner and partner-to-HNF4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSWIM8 grouped by HNF4A-low versus HNF4A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HNF4A→partner) and Y-score (partner→HNF4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZSWIM8 →	+4.053	+4.357	.001	.001	1	4
BLOOD_Lymphoma	TRPV3 →	+4.429	+5.247	.005	.005	1	4
CNS	SH3TC1 →	+5.000	+4.044	.008	.008	1	4
BLOOD_Leukemia	RTL10 →	+4.894	+4.894	.004	.004	1	4
BLOOD_Lymphoma	RAI14 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Lymphoma	ETV1 →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,864 associations by consensus.

ZSWIM8 by HNF4A expression — SKIN

Explore this box plot interactively →