HNF1A

Across TCGA pan-cancer cohorts, HNF1A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HNF1A data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HNF1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HNF1A expression acts as an unfavorable survival marker.

BLCA, LGG, and SKCM are the cancer types where HNF1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.093	0.605	<.001	24	view →
LGG	DFS	Median	All	0.185	0.832	<.001	12	view →
SKCM	DFS	Median	IV	0.052	0.476	.026	6	view →
BRCA	DFS	Median	II,III,IV	0.585	0.889	.004	4	view →
PRAD	OS	Median	All	0.632	0.884	<.001	4	view →
LIHC	DFS	Median	All	0.097	0.553	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HNF1A–BLCA (OS)

Open the BLCA breakdown →