Across TCGA patient cohorts, HMX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,350 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HMX3-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Mesenchymal cell differentiation. Each is linked with HMX3 in more than 12 cancer types. Because this analysis shows association rather than direction, both HMX3-to-partner and partner-to-HMX3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMX3→partner) and Y-score (partner→HMX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	Signal transduction in response to DNA damage →	+0.025	+0.063	<.001	<.001	3	12
MESO	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.032	+0.087	<.001	<.001	3	12
STAD	Mesenchymal cell differentiation →	+0.041	+0.378	<.001	.001	3	12
STAD	Positive regulation of canonical Wnt signaling pathway →	+0.038	+0.323	<.001	.002	2	12
SARC	Positive regulation of organelle assembly →	+0.024	+0.656	<.001	<.001	3	11
ACC	Nuclear envelope organization →	+0.034	+1.893	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,350 associations by consensus.

Exploration

HMX3 survival (RNA) · tumor vs normal (RNA) · all HMX3 data types