Across TCGA cell cohorts, HMX3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HMX3-associated genes across cancer lineages are RPE65, KRTAP6-1, and OOSP4A. Each is linked with HMX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMX3-to-partner and partner-to-HMX3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMX3→partner) and Y-score (partner→HMX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPE65 →	+0.032	+3.475	<.001	.006	3	1
LUNG_NSCLC_LUAD	KRTAP6-1 →	+0.055	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OOSP4A →	+0.039	+4.212	<.001	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.147	+4.145	<.001	.001	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Leukemia	C10orf90 →	+0.070	+3.569	.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HMX3 survival (RNA) · tumor vs normal (RNA) · all HMX3 data types