Across TCGA patient cohorts, HMX2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMX2-associated genes across cancer lineages are EGFR_pY1068, Tuberin, and Caspase-8. Each is linked with HMX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMX2-to-partner and partner-to-HMX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMX2→partner) and Y-score (partner→HMX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.352	-3.000	.015	.037	3	1
UCEC	Tuberin →	+0.371	+2.817	.017	.036	3	1
UCEC	Caspase-8 →	-0.350	-2.973	.016	.035	3	1
UCEC	FoxM1 →	+0.322	+3.000	.031	.037	1	2
UCEC	p62 Lck ligand →	+0.726	+3.000	<.001	.037	1	1
UCEC	Cyclin-B1 →	+0.940	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

HMX2 survival (RNA) · tumor vs normal (RNA) · all HMX2 data types